The 2022 Houston Astros season was the 61st season for the Houston Astros, a Major League Baseball (MLB) franchise located in Houston, Texas, their 58th as the Astros, 10th in both the American League and American League West, and 23rd at Minute Maid Park. The Astros entered the season as both the defending AL champions, and they looked to avenge their 2021 World Series loss to the Atlanta Braves.

Behind Framber Valdez' first Opening Day start, the Astros won for the tenth straight year, which set a modern-day record and tied the Boston Beaneaters (1887–1896) for most consecutive Opening Day victories in major league history. Manager Dusty Baker reached 2,000 career wins on May 3 with a 4–0 win over the Seattle Mariners, becoming the 12th manager to reach the milestone. Two Astros pitchers, Luis García and Phil Maton, each recorded an immaculate inning on June 15, 2022, the first occurrence in major league history of more than one immaculate inning pitched on the same day.

The Astros secured a sixth consecutive playoff berth following a 5–0 win against the Oakland Athletics. On September 19, they clinched their fifth AL West title in the last six seasons following a 4–0 win against the Tampa Bay Rays. They swept Seattle in the ALDS to reach the ALCS for a sixth straight season, in doing so becoming the first team in major league history to win a postseason series in six consecutive seasons. They swept the New York Yankees in the ALCS and defeated the Philadelphia Phillies in six games in the World Series, becoming just the third team after the 1995 Atlanta Braves and the 2019 Washington Nationals to sweep the LCS since it became a best-of-seven-game series and subsequently win the World Series.

On November 5, they beat the Phillies 4–1 in Game 6 at Minute Maid Park to win their second world championship and first since 2017. A historic bullpen that allowed just five earned runs all postseason was boosted by contributions by players such as Jeremy Peña (ALCS and World Series MVP) and Yordan Alvarez (who had go-ahead home runs in three of the eleven Astro postseason wins). Dusty Baker earned his first championship as a manager with the win. The Astros became the first team to have a winning percentage of .622 (or better) in a six-season span (2017–2022) with multiple World Series titles since the 1953–1958 New York Yankees, and they became the sixth team since 1960 to win the World Series after losing it the previous year.